The victory for the Mount was the first win in the all-time series with Loyola in the 10th meeting between the two squads.
The Mount was able to capitalize on its first true scoring opportunity of the contest in the 36th minute. Rookie Hannah Logue worked her way toward the end line and sent a pass to Harmon just outside the six-yard box. Harmon fired a shot towards the upper 90 to beat goalie Sumer Rahe and put the Mount on top, 1-0.
The goal for Harmon was the second of her career, while Logue's assist was the first point of the rookie's career.
Loyola found the equalizer just minutes into the second half as Nicole Rivas scored off a pass from Julianna Cabrera to knot the game at 1-1.
With just over 20 minutes remaining in the tilt, Jenna West sent a well-placed corner kick into the box, and Buonomo, the freshman defender, headed one into the back of the net for her first career goal and the go-ahead score.
Mount St. Mary's got some insurance in the 81st minute as Hughes, a transfer from Villanova, beat Rahe over the top from around 30 yards out to extend the Mount's lead to 3-1.
The Mountaineers held off the Greyhounds in the final nine-plus minutes to close out the win and move to 1-0 on the year.
Rutgers transfer Maggie Barron registered the win in goal for the Mount with a pair of saves, while Rahe took the loss for Loyola.
The Mount returns to Emmitsburg for the home opener on Sunday, August 20 at 4 p.m. Action will be streamed live for free at NECFrontRow.com.